Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/68241
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dc.contributor.author | Deane, A. | - |
dc.contributor.author | Summers, M. | - |
dc.contributor.author | Zaknic, A. | - |
dc.contributor.author | Chapman, M. | - |
dc.contributor.author | Fraser, R. | - |
dc.contributor.author | Di Bartolomeo, A. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Critical Care (UK), 2011; 15(1):1-11 | - |
dc.identifier.issn | 1466-609X | - |
dc.identifier.issn | 1466-609X | - |
dc.identifier.uri | http://hdl.handle.net/2440/68241 | - |
dc.description | Extent: 11p. | - |
dc.description.abstract | Introduction: Glucagon-like peptide-1 (GLP-1) attenuates the glycaemic response to small intestinal nutrient infusion in stress-induced hyperglycaemia and reduces fasting glucose concentrations in critically ill patients with type-2 diabetes. The objective of this study was to evaluate the effects of acute administration of GLP-1 on the glycaemic response to small intestinal nutrient infusion in critically ill patients with pre-existing type-2 diabetes. Methods: Eleven critically ill mechanically-ventilated patients with known type-2 diabetes received intravenous infusions of GLP-1 (1.2 pmol/kg/minute) and placebo from t = 0 to 270 minutes on separate days in randomised double-blind fashion. Between t = 30 to 270 minutes a liquid nutrient was infused intraduodenally at a rate of 1 kcal/min via a naso-enteric catheter. Blood glucose, serum insulin and C-peptide, and plasma glucagon were measured. Data are mean ± SEM. Results: GLP-1 attenuated the overall glycaemic response to nutrient (blood glucose AUC30-270 min: GLP-1 2,244 ± 184 vs. placebo 2,679 ± 233 mmol/l/minute; P = 0.02). Blood glucose was maintained at < 10 mmol/l in 6/11 patients when receiving GLP-1 and 4/11 with placebo. GLP-1 increased serum insulin at 270 minutes (GLP-1: 23.4 ± 6.7 vs. placebo: 16.4 ± 5.5 mU/l; P < 0.05), but had no effect on the change in plasma glucagon. Conclusions: Exogenous GLP-1 in a dose of 1.2 pmol/kg/minute attenuates the glycaemic response to small intestinal nutrient in critically ill patients with type-2 diabetes. Given the modest magnitude of the reduction in glycaemia the effects of GLP-1 at higher doses and/or when administered in combination with insulin, warrant evaluation in this group. | - |
dc.description.statementofresponsibility | Adam M Deane, Matthew J Summers, Antony V Zaknic, Marianne J Chapman, Robert JL Fraser, Anna E Di Bartolomeo, Judith M Wishart, Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Current Science Ltd | - |
dc.rights | © 2011 Deane et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.source.uri | http://dx.doi.org/10.1186/cc9983 | - |
dc.subject | Pylorus | - |
dc.subject | Humans | - |
dc.subject | Diabetes Mellitus, Type 2 | - |
dc.subject | Critical Illness | - |
dc.subject | Blood Glucose | - |
dc.subject | Hypoglycemic Agents | - |
dc.subject | Treatment Outcome | - |
dc.subject | Enteral Nutrition | - |
dc.subject | Critical Care | - |
dc.subject | Double-Blind Method | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.title | Exogenous glucagon-like peptide-1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients with type-2 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/cc9983 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Deane, A. [0000-0002-7620-5577] | - |
dc.identifier.orcid | Chapman, M. [0000-0003-0710-3283] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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