Adelaide Research & Scholarship
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https://hdl.handle.net/2440/68553
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| Type: | Journal article |
| Title: | Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription |
| Other Titles: | Total synthesis of (+) - A83586C, (+)- kettapeptin and (+)- azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription |
| Author: | Hale, K. Manaviazar, S. George, J. |
| Citation: | Chemical Communications, 2010; 46(23):4021-4042 |
| Publisher: | Royal Soc Chemistry |
| Issue Date: | 2010 |
| ISSN: | 1359-7345 1364-548X |
| Statement of Responsibility: | Karl J. Hale, Soraya Manaviazar and Jonathan George |
| Abstract: | Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations. |
| Keywords: | Cell Line, Tumor Humans Colonic Neoplasms Depsipeptides Peptides Transcription Factors Transcription, Genetic E2F Transcription Factors beta Catenin Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Transcription Factor 4 |
| Rights: | This journal is copyright The Royal Society of Chemistry 2010 |
| DOI: | 10.1039/C000603C |
| Published version: | http://dx.doi.org/10.1039/c000603c |
| Appears in Collections: | Aurora harvest Chemistry publications |
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