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https://hdl.handle.net/2440/71412
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Type: | Journal article |
Title: | Necrotizing myopathy: Clinicoserologic associations |
Author: | Ellis, E. Tan, J. Lester, S. Tucker, G. Blumbergs, P. Roberts-Thomson, P. Limaye, V. |
Citation: | Muscle and Nerve, 2012; 45(2):189-194 |
Publisher: | John Wiley & Sons Inc |
Issue Date: | 2012 |
ISSN: | 0148-639X 1097-4598 |
Statement of Responsibility: | Elizabeth Ellis, Ju Ann Tan, Sue Lester, Graeme Tucker, Peter Blumbergs, Peter Roberts-Thomson and Vidya Limaye |
Abstract: | <h4>Introduction</h4>Necrotizing myopathy (NM) is distinguished from idiopathic inflammatory myositis (IIM) by dominance of myofiber necrosis, lack of mononuclear inflammatory infiltrates, and presence of antibodies to signal recognition particle (SRP).<h4>Methods</h4>The clinical features of 64 cases of NM were determined. Measurement of autoantibodies was undertaken on stored sera from 23 patients with NM. The incidence of malignancy was determined from the South Australian Cancer Registry.<h4>Results</h4>NM patients showed male predominance (61%), more frequent myalgias, and higher creatine kinase (CK) levels compared with IIM patients. Patients with NM had a high incidence of systemic lupus erythematosus (SLE) (21%), hypertension (11 of 17, 65%), and diabetes mellitus (3 of 13, 23%). No patient had antibodies to SRP. NM patients showed no altered risk for malignancy compared with the South Australian population (P = 0.86).<h4>Conclusions</h4>NM is associated with SLE, hypertension, and diabetes mellitus. Comprehensive assessment of cardiovascular risk is indicated in NM, which raises the possibility of targeted interventions. |
Keywords: | anti-SRP autoantibodies idiopathic inflammatory myopathy myositis-associated antibodies necrotizing myopathy systemic lupus erythematosus |
Rights: | Copyright © 2011 Wiley Periodicals, Inc. |
DOI: | 10.1002/mus.22279 |
Published version: | http://dx.doi.org/10.1002/mus.22279 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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