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https://hdl.handle.net/2440/71993
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Type: | Journal article |
Title: | Aquaporin-4 expression after experimental contusional injury in an ovine impact-acceleration head injury model |
Author: | Finnie, J. Blumbergs, P. Manavis, J. |
Citation: | Journal of Clinical Neuroscience, 2011; 18(7):947-950 |
Publisher: | Churchill Livingstone |
Issue Date: | 2011 |
ISSN: | 0967-5868 1532-2653 |
Statement of Responsibility: | John W. Finnie, Peter C. Blumbergs and Jim Manavis |
Abstract: | Cerebral contusions are one of the principal lesions of traumatic brain injury and the attendant oedema formation contributes substantially to the clinicopathological manifestations. While it is now recognised that the membrane channel protein aquaporin-4 (AQP-4) plays a major role in the development and resolution of cerebral oedema, assessments of its expression in and around contusions have produced conflicting results. We used an ovine impact-acceleration model of closed head injury to examine contusion-related AQP-4 expression and found that there was a heterogeneous AQP-4 response within contusions, with some astrocytes being nonviable and immunonegative, while others showed increased AQP-4 expression. Pericontusional astrocytes in the penumbra region generally showed more robust AQP-4 immunopositivity than intracontusional glia. Thus, manipulation of AQP-4 expression could have therapeutic applications in controlling cerebral oedema associated with contusions. |
Keywords: | Astrocytes Animals Sheep Brain Edema Brain Injuries Head Injuries, Closed Disease Models, Animal Immunohistochemistry Female Aquaporin 4 |
Rights: | © 2011 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.jocn.2010.11.010 |
Published version: | http://dx.doi.org/10.1016/j.jocn.2010.11.010 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest |
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