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https://hdl.handle.net/2440/72625
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dc.contributor.author | Stevens, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Deacon, C. | - |
dc.contributor.author | Nauck, M. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Jones, K. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Alimentary Pharmacology and Therapeutics, 2012; 36(4):379-390 | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.issn | 1365-2036 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72625 | - |
dc.description.abstract | <h4>Background</h4>The rate of gastric emptying (GE) and subsequent release of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are critical determinants of postprandial glycaemia in health and type 2 diabetes. Slowing of GE may be the dominant mechanism by which exogenous GLP-1, and some GLP-1 analogues, improve postprandial glycaemia.<h4>Aim</h4>To determine the effect of sitagliptin on GE in healthy subjects, and the relationships between GE with glycaemia and incretin hormone secretion.<h4>Methods</h4>Fifteen volunteers (22.8 ± 0.7 years) were studied on two occasions following 2 days dosing with sitagliptin (100 mg/day) or placebo. GE (scintigraphy), glycaemia and plasma GLP-1 and GIP (total and intact), insulin and glucagon were measured for 240 min following a mashed potato meal (1808 kJ).<h4>Results</h4>There was no difference in GE between sitgaliptin and placebo [50% emptying time (T50): P = 0.4]. Mean blood glucose was slightly less (P = 0.02) on sitagliptin. Sitagliptin reduced plasma glucagon between 75 and 120 min (P < 0.05), and increased intact GLP-1 (P = 0.0002) and intact GIP (P = 0.0001) by approximately twofold, but reduced total GIP (P = 0.0003) and had no effect on total GLP-1 (P = 0.16) or insulin (P = 0.75). On sitagliptin the initial rise in blood glucose (r = -0.66, P = 0.008) and the intact GIP response (r = -0.66, P = 0.007) were inversely related, whereas the intact GLP-1 response was related directly (r = 0.52, P = 0.05) to the T50.<h4>Conclusions</h4>While the effects of sitagliptin on glycaemic control are unlikely to relate to slowing of GE in healthy humans, the rate of GE is a significant determinant of postprandial glycaemia on sitagliptin. | - |
dc.description.statementofresponsibility | J. E. Stevens, M. Horowitz, C. F. Deacon, M. Nauck, C. K. Rayner & K. L. Jones | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.rights | © 2012 Blackwell Publishing Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-2036.2012.05198.x | - |
dc.subject | Humans | - |
dc.subject | Triazoles | - |
dc.subject | Pyrazines | - |
dc.subject | Gastric Inhibitory Polypeptide | - |
dc.subject | Glucagon | - |
dc.subject | Insulin | - |
dc.subject | Blood Glucose | - |
dc.subject | Gastric Emptying | - |
dc.subject | Intestinal Absorption | - |
dc.subject | Postprandial Period | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.subject | Dipeptidyl-Peptidase IV Inhibitors | - |
dc.subject | Young Adult | - |
dc.subject | Sitagliptin Phosphate | - |
dc.title | The effects of sitagliptin on gastric emptying in healthy humans - a randomised, controlled study | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-2036.2012.05198.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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