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https://hdl.handle.net/2440/72835
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Type: | Journal article |
Title: | Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies |
Author: | Weekley, C. Aitken, J. Musgrave, I. Harris, H. |
Citation: | Biochemistry, 2012; 51(3):736-738 |
Publisher: | American Chemical Society |
Issue Date: | 2012 |
ISSN: | 0006-2960 1520-4995 |
Statement of Responsibility: | Claire M. Weekley, Jade B. Aitken, Ian F. Musgrave, and Hugh H. Harris |
Abstract: | The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical form of selenium in human neuroblastoma cells. Cells treated with MeSeCys contain a significant diselenide component, which is absent from SeMet-treated cells and suggests that metabolites of MeSeCys are capable of altering the redox status of the cells. The differences in the speciation of Se in the selenoamino acid-treated cells may provide insight into the differing anticancer activities of MeSeCys and SeMet. |
Keywords: | Cell Line, Tumor Humans Selenium Compounds Benzene Derivatives Organoselenium Compounds Selenocysteine Cysteine Antineoplastic Agents X-Ray Absorption Spectroscopy |
Rights: | Copyright © 2012 American Chemical Society |
DOI: | 10.1021/bi201462u |
Grant ID: | http://purl.org/au-research/grants/arc/DP0985807 |
Published version: | http://dx.doi.org/10.1021/bi201462u |
Appears in Collections: | Aurora harvest 5 Environment Institute publications IPAS publications |
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