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https://hdl.handle.net/2440/73086
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Type: | Journal article |
Title: | Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis |
Author: | Graf, S. Lester, S. Nossent, J. Hill, C. Proudman, S. Lee, A. Rischmueller, M. |
Citation: | Arthritis Research and Therapy, 2012; 14(1):1-7 |
Publisher: | BioMed Central Ltd. |
Issue Date: | 2012 |
ISSN: | 1478-6354 1478-6362 |
Statement of Responsibility: | Scott W Graf, Sue Lester, Johannes C Nossent, Catherine L Hill, Susanna M Proudman, Anita Lee and Maureen Rischmueller |
Abstract: | Introduction: Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether low CN of the FCGR3B gene is associated with susceptibility to RA. Method: The FCGR3B CN was determined using a custom Taqman® CN assay (Hs04211858; Applied Biosystems, Foster City, CA, USA) in 197 RA patients, recruited from a tertiary setting, and in 162 population matched controls. Odds ratios for low CN (< 2) and high CN (> 2), both relative to the normal diploid 2CN, were estimated by logistic regression. Results: A significant association between RA and low FCGR3B CN was observed, with frequencies of 13.7% in RA patients compared with 6.2% in controls (odds ratio 2.5, 95% confidence interval 1.2 to 5.4, P = 0.017). No association was observed between low CN and the presence of rheumatoid factor, anti-cyclic citrullinated peptide antibodies or radiographic erosions in RA patients. A meta-analysis including six previous studies confirmed an association between RA and low FCGR3B CN (odds ratio 1.47, 95% confidence interval 1.13 to 1.92, P = 0.004). Conclusions: The present study confirms that a low CN of the FCGR3B gene is associated with susceptibility to RA. The association may be stronger in patients recruited from a tertiary setting, which may relate to disease severity and/or complications. The mechanism of susceptibility remains unclear and further study is required. |
Keywords: | Humans Arthritis, Rheumatoid Genetic Predisposition to Disease Receptors, IgG DNA Logistic Models Case-Control Studies Polymerase Chain Reaction Gene Dosage Middle Aged Female Male DNA Copy Number Variations GPI-Linked Proteins Tertiary Care Centers |
Rights: | © 2012 Graf et al.; licensee BioMed Central Ltd.This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/ar3731 |
Published version: | http://arthritis-research.com/content/14/1/R28 |
Appears in Collections: | Aurora harvest Medicine publications |
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