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https://hdl.handle.net/2440/74027
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Type: | Journal article |
Title: | Substrate and trigger ablation for reduction of atrial fibrillation trial - Part II (STAR AF II): design and rationale |
Author: | Verma, A. Sanders, P. MacLe, L. Deisenhofer, I. Morillo, C. Chen, J. Jiang, C. Ernst, S. Mantovan, R. |
Citation: | American Heart Journal, 2012; 164(1):1-12 |
Publisher: | Mosby Inc |
Issue Date: | 2012 |
ISSN: | 0002-8703 1097-6744 |
Statement of Responsibility: | Atul Verma, Prashanthan Sanders, Laurent Macle, Isabel Deisenhofer, Carlos A. Morillo, Jian Chen, Chen-yang Jiang, Sabine Ernst and Roberto Mantovan |
Abstract: | <h4>Background</h4>The optimal ablation approach for patients with persistent atrial fibrillation (AF) remains unknown. In particular, it is unclear if pulmonary vein (PV) antral isolation (PVI) is sufficient as a lone strategy for persistent AF. Furthermore, if additional substrate ablation is to be added, the ideal approach to substrate ablation is yet to be determined.<h4>Objective</h4>The aim of this study is to determine the optimal strategy of catheter ablation of persistent AF by comparing the efficacy of 3 strategies: PVI vs PVI plus complex fractionated electrogram (CFE) ablation (PVI + CFE) vs PVI plus linear ablation (PVI + Lines).<h4>Study design</h4>The STAR AF II study (ClinicalTrials.gov NCT01203748) is a prospective, multicenter, randomized trial with a blinded assessment of outcomes. A total of 549 patients will be randomized in a 1:4:4 fashion to one of the investigation arms: PVI, PVI + CFE, and PVI + Lines, respectively. Patients undergoing a first-time ablation procedure for symptomatic, persistent AF that is refractory to at least 1 antiarrhythmic medication will be included. Persistent AF will be defined as a sustained episode lasting >7 days and <3 years. Patients with a left atrial parasternal size ≥60 mm will be excluded. The primary end point is freedom from documented AF >30 seconds at 18 months after 1 or 2 ablation procedures with or without antiarrhythmic medications.<h4>Conclusions</h4>The STAR AF II study is a randomized trial designed to evaluate the optimal approach for catheter ablation of persistent AF. |
Keywords: | Humans Atrial Fibrillation Catheter Ablation Prospective Studies Single-Blind Method Randomized Controlled Trials as Topic |
Rights: | © 2012, Mosby, Inc. All rights reserved. |
DOI: | 10.1016/j.ahj.2012.04.002 |
Published version: | http://dx.doi.org/10.1016/j.ahj.2012.04.002 |
Appears in Collections: | Aurora harvest Medicine publications |
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