Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/78337
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Overview of biomarkers in metastatic colorectal cancer: tumour, blood and patient-related factors |
Author: | Clarke, S. Karapetis, C. Gibbs, P. Pavlakis, N. Desai, J. Michael, M. Tebbutt, N. Price, T. Tabernero, J. |
Citation: | Critical Reviews in Oncology Hematology, 2013; 85(2):121-135 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2013 |
ISSN: | 1040-8428 1879-0461 |
Statement of Responsibility: | Stephen J. Clarke, Christos S. Karapetis, Peter Gibbs, Nick Pavlakis, Jayesh Desai, Michael Michael, Niall C. Tebbutt, Tim J. Price and Josep Tabernero |
Abstract: | During the last 20 years there have been major therapeutic developments in colorectal cancer (CRC) with the introduction of multiple novel therapeutic agents into routine clinical practice. This has improved survival in both the adjuvant and advanced disease settings. However, improvements have come with substantial increases in expense to the community and potential toxicity to the patient. There has been substantial research to identify tumour factors in CRC that predict treatment response and survival outcomes. This research has identified clinically useful predictive biomarkers to aid clinical decision making, such as the presence or absence of KRAS gene mutations which can determine the benefit of using epidermal growth factor receptor (EGFR) inhibiting antibodies. However, less attention has been paid to the identification and impact of predictive patient-derived factors such as age, gender and the presence of comorbid conditions or evidence of a systemic inflammatory response. In this article, the current concepts of tumour and patient-related predictive factors in CRC management are reviewed. |
Keywords: | Humans Colorectal Neoplasms Neoplasm Metastasis Prognosis Treatment Outcome Risk Factors Biotechnology Biomarkers, Tumor |
Rights: | © 2012 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.critrevonc.2012.06.001 |
Published version: | http://dx.doi.org/10.1016/j.critrevonc.2012.06.001 |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.