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https://hdl.handle.net/2440/7859
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Type: | Journal article |
Title: | Insulin-like growth factor-I partially attenuates colonic damage in rats with experimental colitis induced by oral dextran sulphate sodium |
Author: | Howarth, G. Xian, C. Read, L. |
Citation: | Scandinavian Journal of Gastroenterology, 1998; 33(2):180-190 |
Publisher: | TAYLOR & FRANCIS LTD |
Issue Date: | 1998 |
ISSN: | 0036-5521 1502-7708 |
Abstract: | <h4>Background</h4>Administration of insulin-like growth factor-I (IGF-I) results in selective growth of the gastrointestinal tract. We investigated the effects of IGF-I on the colonic damage induced by oral dextran sulphate sodium (DSS) in the rat.<h4>Methods</h4>Rats consumed 2% DSS in the drinking water for 10 days to induce colitis. Pumps were implanted on day 3 to deliver IGF-I for 7 days. Colonic histopathology and immunolocalization of transforming growth factor-beta1 (TGF-beta1) were assessed on day 10.<h4>Results</h4>Compared with the colon of vehicle-treated rats consuming DSS, IGF-I increased the numbers of goblet cells by 76%, reduced the proportion of lamina propria cells expressing TGF-beta1, and reduced the thickness of submucosal and muscularis externa layers by 26% and 20%, respectively.<h4>Conclusions</h4>We conclude that the effects of IGF-I treatment on the colonic epithelium may be mediated directly, whereas the reduced inflammation in the mucosa and submucosa may be mediated by a mechanism other than up-regulation of TGF-beta1-mediated immunosuppression. |
Keywords: | Intestinal Mucosa Colon Animals Rats Rats, Sprague-Dawley Colitis, Ulcerative Body Weight Dextran Sulfate Transforming Growth Factor beta Insulin-Like Growth Factor I Organ Size Immunohistochemistry Dose-Response Relationship, Drug Male |
DOI: | 10.1080/00365529850166923 |
Published version: | http://dx.doi.org/10.1080/00365529850166923 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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