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https://hdl.handle.net/2440/808
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Type: | Journal article |
Title: | Correlation of cell disruption with homogeniser valve pressure gradient determined by computational fluid dynamics |
Author: | Kleinig, A. Middelberg, A. |
Citation: | Chemical Engineering Science, 1996; 51(23):5103-5110 |
Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
Issue Date: | 1996 |
ISSN: | 0009-2509 |
Abstract: | Numerical investigations of the flow and pressure fields within a homogenizer valve have been conducted using the computational fluid dynamics code, PHOENICS 2.1. Results are obtained for two valve seat designs over a range of valve gaps. The dependence of valve gap on operating pressure is measured experimentally and compares well with numerical predictions. A simple expression that uses the numerical results and allows ready calculation of pressure gradient from homogenizer operating and design conditions is presented. Pressure gradient is shown to be a better independent variable for correlating cell disruption than operating pressure over a wide range of operating and design parameters. |
DOI: | 10.1016/S0009-2509(96)00354-5 |
Published version: | http://dx.doi.org/10.1016/s0009-2509(96)00354-5 |
Appears in Collections: | Aurora harvest 2 Chemical Engineering publications |
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