Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/82665
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Type: | Journal article |
Title: | Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health |
Author: | Phungamla Vashum, K. McEvoy, M. Shi, Z. Milton, A. Islam, M. Sibbritt, D. Patterson, A. Byles, J. Loxton, D. Attia, J. |
Citation: | BMC Endocrine Disorders, 2013; 13(1):1-8 |
Publisher: | BioMed Central Ltd |
Issue Date: | 2013 |
ISSN: | 1472-6823 1472-6823 |
Statement of Responsibility: | Khanrin Phungamla Vashum, Mark McEvoy, Zumin Shi, Abul Hasnat Milton, Md Rafiqul Islam, David Sibbritt, Amanda Patterson, Julie Byles, Deborah Loxton and John Attia |
Abstract: | BACKGROUND Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women. METHODS Data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women’s Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression. RESULTS From 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32–0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates. CONCLUSIONS Higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes. |
Keywords: | Diabetes Australia Women & Zinc |
Rights: | © 2013 Vashum et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/1472-6823-13-40 |
Published version: | http://dx.doi.org/10.1186/1472-6823-13-40 |
Appears in Collections: | Aurora harvest Medicine publications |
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hdl_82665.pdf | Published version | 206.39 kB | Adobe PDF | View/Open |
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