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https://hdl.handle.net/2440/8267
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dc.contributor.author | Moran, L. | - |
dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Clifton, P. | - |
dc.contributor.author | Wittert, G. | - |
dc.contributor.author | Tomlinson, L. | - |
dc.contributor.author | Galletly, C. | - |
dc.contributor.author | Luscombe-Marsh, N. | - |
dc.contributor.author | Norman, R. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2004; 89(7):3337-3344 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8267 | - |
dc.description | Copyright © 2004 by The Endocrine Society | - |
dc.description.abstract | Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age associated with obesity. It may involve dysregulation of ghrelin, a hormone implicated in appetite regulation. The effect of diet composition on ghrelin is unclear. Overweight women with and without PCOS were randomized to a high-protein (40% carbohydrate, 30% protein; 10 PCOS, six non-PCOS) or standard protein diet (55% carbohydrate, 15% protein; 10 PCOS, six non-PCOS) for 12 wk of energy restriction and 4 wk of weight maintenance. Diet composition had no effect on fasting or postprandial ghrelin or measures of satiety. Non-PCOS subjects had a 70% higher fasting baseline ghrelin (P = 0.011), greater increase in fasting ghrelin (57.5 vs. 34.0%, P = 0.033), and greater maximal decrease in postprandial ghrelin after weight loss (–144.1 ± 58.4 vs. –28.9 ± 14.2 pg/ml, P = 0.02) than subjects with PCOS. Subjects with PCOS were less satiated (P = 0.001) and more hungry (P = 0.007) after a test meal at wk 0 and 16 than subjects without PCOS. Appetite regulation, as measured by subjective short-term hunger and satiety and ghrelin homeostasis, may be impaired in PCOS. | - |
dc.description.statementofresponsibility | L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe and R. J. Norman | - |
dc.language.iso | en | - |
dc.publisher | Endocrine Society | - |
dc.source.uri | http://jcem.endojournals.org/cgi/content/abstract/89/7/3337 | - |
dc.subject | Humans | - |
dc.subject | Polycystic Ovary Syndrome | - |
dc.subject | Obesity | - |
dc.subject | Body Weight | - |
dc.subject | Insulin | - |
dc.subject | Peptide Hormones | - |
dc.subject | Blood Glucose | - |
dc.subject | Dietary Proteins | - |
dc.subject | Pain Measurement | - |
dc.subject | Caloric Restriction | - |
dc.subject | Diet | - |
dc.subject | Fasting | - |
dc.subject | Regression Analysis | - |
dc.subject | Patient Compliance | - |
dc.subject | Satiety Response | - |
dc.subject | Body Composition | - |
dc.subject | Homeostasis | - |
dc.subject | Postprandial Period | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Ghrelin | - |
dc.title | Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/jc.2003-031583 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Moran, L. [0000-0001-5772-6484] | - |
dc.identifier.orcid | Clifton, P. [0000-0002-6411-626X] | - |
dc.identifier.orcid | Wittert, G. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Galletly, C. [0000-0001-6185-9677] | - |
dc.identifier.orcid | Luscombe-Marsh, N. [0000-0001-9690-4722] | - |
dc.identifier.orcid | Norman, R. [0000-0002-3118-3896] | - |
Appears in Collections: | Aurora harvest Medicine publications Obstetrics and Gynaecology publications Psychiatry publications |
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