Highly ordered titania (TiO₂) nanotube arrays fabricated by electrochemical self-ordering process toward development of implantable drug delivery devices with triggered drug release

Abstract

The attractiveness of sell-ordered electrochemical synthesis of nanopore and nanotube arrays is based on its' simplicity, low cost and nanoscale precision to create highly-organized and uniform structures with controllable dimensions and unique properties. In this work the fabrication of titania nanotubes (TNT) array and their application as implantable drug delivery platform is explored. Prepared TNT were loaded with anti-inflammatory drug (indomethacin). Sustained drug release including triggered release by external magnetic field from TNT implant was monitored by UV-VIS and reflective interference spectroscopy.