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https://hdl.handle.net/2440/8581
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Type: | Journal article |
Title: | Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility |
Author: | Sun, W.M. Doran, S. Jones, K. Ooi, E. Boeckxstaens, G. Hebbard, G. Lingenfelser, T. Morley, J. Dent, J. Horowitz, M. |
Citation: | American Journal of Physiology: Gastrointestinal and Liver Physiology, 1998; 275(5):G1173-G1178 |
Publisher: | American Physiological Society |
Issue Date: | 1998 |
ISSN: | 1522-1547 1522-1547 |
Statement of Responsibility: | W.-M. Sun, S. Doran, K. L. Jones, E. Ooi, G. Boeckxstaens, G. S. Hebbard, T. Lingenfelser, J. E. Morley, J. Dent, M. Horowit |
Abstract: | The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19-36 yr). Antropyloroduodenal pressures were recorded with a manometric assembly that had nine side holes spanning the antrum and proximal duodenum and a pyloric sleeve sensor; gastric emptying was quantified scintigraphically. In each subject, the emptying of 300 ml of 25% glucose labeled with 99mTc was assessed on two separate days during intravenous infusion of either nitroglycerin (5 micrograms/min in 5% dextrose) or 5% dextrose (control). Studies were performed with the subject in the supine position; blood pressure and heart rate were monitored. Nitroglycerin had no significant effect on blood pressure or heart rate. Nitroglycerin slowed gastric emptying (P < 0.02), and this was associated with greater retention of the drink in the proximal stomach (P < 0.05). In both nitroglycerin and control studies, ingestion of the drink was associated with an increase in the number of isolated pyloric pressure waves (P < 0.05) and antral pressure wave sequences (P < 0.05). Nitroglycerin reduced the number of isolated pyloric pressure waves (P < 0.05), basal pyloric pressure (P < 0.05), and the number of antral pressure wave sequences (P < 0. 05), but not the total number of antral pressure waves. The rate of gastric emptying and the number of isolated pyloric pressure waves were inversely related during control (P = 0.03) and nitroglycerin (P < 0.05) infusions. We conclude that in normal subjects, 1) gastric emptying of 300 ml of 25% glucose is inversely related to the frequency of phasic pyloric pressure waves, and 2) nitroglycerin in a dose of 5 micrograms/min inhibits pyloric motility, alters the organization but not the number of antral pressure waves, and slows gastric emptying and intragastric distribution of 25% glucose. |
Keywords: | Antrum pyloricum Duodenum Gastric emptying Nitric oxide Nutrition Nitroglycerin Organic nitrate Human Motility Stomach Digestive system Small intestine |
Rights: | © 1998, The American Physiological Society |
DOI: | 10.1152/ajpgi.1998.275.5.g1173 |
Published version: | http://ajpgi.physiology.org/content/275/5/G1173 |
Appears in Collections: | Aurora harvest Medicine publications |
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