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https://hdl.handle.net/2440/8621
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Type: | Journal article |
Title: | The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis |
Author: | Brown, M. Kennedy, L. Darke, C. Gibson, K. Pile, K. Shatford, J. Taylor, A. Calin, A. Wordsworth, B. |
Citation: | Arthritis and Rheumatism, 1998; 41(3):460-465 |
Publisher: | Wiley |
Issue Date: | 1998 |
ISSN: | 0004-3591 |
Statement of Responsibility: | Matthew A. Brown, L. Gail Kennedy, Chris Darke, Kathryn Gibson, Kevin D. Pile, Jane L. Shatford, Andrew Taylor, Andrei Calin, B. Paul Wordsworth |
Abstract: | Objective: To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS). Methods: Three hundred sixty-three white British AS patients were studied; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire. Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based methods. HLA data from 13,634 healthy white British bone marrow donors were used for comparison. Results: A significant association between DR1 and AS was found, independent of HLA-B27 (overall odds ratio [OR] 1.4, 95% confidence interval [95% CI] 1.1-1.8, P = 0.02; relative risk [RR] 2.7, 95% CI 1.5-4.8, P = 6 × 10-4 among homozygotes; RR 2.1, 95% CI 1.5-2.8, P = 5 × 10-6 among heterozygotes). A large but weakly significant association between DR8 and AS was noted, particularly among DR8 homozygotes (RR 6.8, 95% CI 1.6-29.2, P = 0.01 among homozygotes; RR 1.6, 95% CI 1.0-2.7, P = 0.07 among heterozygotes). A negative association with DR12 (OR 0.22, 95% CI 0.09-0.5, P = 0.001) was noted. HLA-DR7 was associated with younger age at onset of disease (mean age at onset 18 years for DR7-positive patients and 23 years for DR7-negative patients; Z score 3.21, P = 0.001). No other HLA class I or class II associations with disease severity or with different clinical manifestations of AS were found. Conclusion: The results of this study suggest that HLA-DR genes may have a weak effect on susceptibility to AS independent of HLA-B27, but do not support suggestions that they affect disease severity or different clinical manifestations. |
Description: | Article first published online: 28 MAY 2004 |
Rights: | © 1998, American College of Rheumatology |
DOI: | 10.1002/1529-0131(199803)41:3<460::AID-ART12>3.0.CO;2-X |
Published version: | http://onlinelibrary.wiley.com/doi/10.1002/1529-0131(199803)41:3%3C460::AID-ART12%3E3.0.CO;2-X/abstract |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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