Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/86998
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dc.contributor.author | Bariana, M. | - |
dc.contributor.author | Aw, M. | - |
dc.contributor.author | Moore, E. | - |
dc.contributor.author | Voelcker, N. | - |
dc.contributor.author | Losic, D. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Nanomedicine, 2014; 9(8):1263-1275 | - |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.issn | 1748-6963 | - |
dc.identifier.uri | http://hdl.handle.net/2440/86998 | - |
dc.description.abstract | AIM: This study aimed to demonstrate radiofrequency (RF)-triggered release of drugs and drug carriers from drug-eluting implants using gold nanoparticles as energy transducers. MATERIALS & METHODS: Titanium wire with a titania nanotube layer was used as an implant loaded with indomethacin and micelles (tocopheryl PEG succinate) as a drug and drug carrier model. RF signals were generated from a customized RF generator to trigger in vitro release. RESULTS & DISCUSSION: Within 2.5 h, 18 mg (92%) of loaded drug and 14 mg (68%) of loaded drug carriers were released using short RF exposure (5 min), compared with 5 mg (31%) of drug and 2 mg (11%) of drug carriers without a RF trigger. Gold nanoparticles can effectively function as RF energy transducers inside titania nanotubes for rapid release of therapeutics at arbitrary times. CONCLUSION: The results of this study show that RF is a promising strategy for triggered release from implantable drug delivery systems where on-demand delivery of therapeutics is required. | - |
dc.description.statementofresponsibility | Manpreet Bariana, Moom Sinn Aw, Eli Moore, Nicolas H Voelcker, Dusan Losic | - |
dc.language.iso | en | - |
dc.publisher | Future Medicine | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.2217/nnm.13.93 | - |
dc.subject | drug-eluting implant | - |
dc.subject | gold nanoparticle | - |
dc.subject | micelle | - |
dc.subject | noninvasive drug delivery | - |
dc.subject | polymer | - |
dc.subject | radiofrequency | - |
dc.subject | titania nanotube | - |
dc.subject | triggered drug release | - |
dc.subject | water-insoluble drug | - |
dc.title | Radiofrequency-triggered release for on-demand delivery of therapeutics from titania nanotube drug-eluting implants | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2217/nnm.13.93 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT110100711 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP120101680 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Losic, D. [0000-0002-1930-072X] | - |
Appears in Collections: | Aurora harvest 7 Chemical Engineering publications |
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