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https://hdl.handle.net/2440/87469
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dc.contributor.author | Nguyen, N. | - |
dc.contributor.author | Debreceni, T. | - |
dc.contributor.author | Bambrick, J. | - |
dc.contributor.author | Chia, B. | - |
dc.contributor.author | Deane, A. | - |
dc.contributor.author | Wittert, G. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Young, R. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Obesity, 2014; 22(10):2164-2171 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.issn | 1930-739X | - |
dc.identifier.uri | http://hdl.handle.net/2440/87469 | - |
dc.description.abstract | OBJECTIVE: To determine the effect of Roux-en-Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia. METHODS: Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT-1 and GLUT2) from 11 non-diabetic RYGB, 13 non-diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3-O-methyl-d-glucopyranose (3-OMG)). Blood glucose, plasma 3-OMG, and insulin were measured for 270 min. RESULTS: In RYGB patients, expression of both GTs was ∼2-fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P < 0.001). STR expressions were comparable amongst the groups. Peak plasma 3-OMG in both RYGB (r = 0.69, P = 0.01) and obese (r = 0.72, P = 0.005) correlated with baseline expression of SGLT-1, as was the case with peak blood glucose in RYGB subjects (r = 0.69, P = 0.02). CONCLUSIONS: The upregulated intestinal GTs in RYGB patients are associated with increased glucose absorption when glucose is delivered at a physiological rate, suggesting a molecular adaptation to prevent carbohydrate malabsorption from rapid intestinal transit after RYGB. | - |
dc.description.statementofresponsibility | Nam Q. Nguyen, Tamara L. Debreceni, Jenna E. Bambrick, Bridgette Chia, Adam M. Deane, Gary Wittert, Chris K. Rayner, Michael Horowitz and Richard L. Young | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2014 The Obesity Society | - |
dc.source.uri | http://dx.doi.org/10.1002/oby.20829 | - |
dc.subject | Intestinal Mucosa | - |
dc.subject | Humans | - |
dc.subject | Malabsorption Syndromes | - |
dc.subject | Obesity, Morbid | - |
dc.subject | Insulin | - |
dc.subject | Glucose | - |
dc.subject | Blood Glucose | - |
dc.subject | Gastric Bypass | - |
dc.subject | Case-Control Studies | - |
dc.subject | Up-Regulation | - |
dc.subject | Intestinal Absorption | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Carbohydrate Metabolism | - |
dc.subject | Glucose Transport Proteins, Facilitative | - |
dc.title | Upregulation of intestinal glucose transporters after Roux-en-Y gastric bypass to prevent carbohydrate malabsorption | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/oby.20829 | - |
dc.relation.grant | NFC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Nguyen, N. [0000-0002-1270-5441] | - |
dc.identifier.orcid | Deane, A. [0000-0002-7620-5577] | - |
dc.identifier.orcid | Wittert, G. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Young, R. [0000-0001-5116-4951] [0009-0004-8274-9863] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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