Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8875
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DC Field | Value | Language |
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dc.contributor.author | Kumar, S. | - |
dc.contributor.author | White, D. | - |
dc.contributor.author | Takai, S. | - |
dc.contributor.author | Turczynowicz, S. | - |
dc.contributor.author | Juttner, C. | - |
dc.contributor.author | Hughes, T. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Human Genetics, 1995; 95(6):641-644 | - |
dc.identifier.issn | 0340-6717 | - |
dc.identifier.issn | 1432-1203 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8875 | - |
dc.description.abstract | Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed. | - |
dc.language.iso | en | - |
dc.publisher | Springer International | - |
dc.source.uri | http://dx.doi.org/10.1007/bf00209480 | - |
dc.subject | Blood Cells | - |
dc.subject | Chromosomes, Human, Pair 7 | - |
dc.subject | Humans | - |
dc.subject | Leukemia | - |
dc.subject | Lymphoma | - |
dc.subject | Cysteine Endopeptidases | - |
dc.subject | In Situ Hybridization, Fluorescence | - |
dc.subject | Chromosome Mapping | - |
dc.subject | Apoptosis | - |
dc.subject | Genes, Regulator | - |
dc.subject | Caspase 2 | - |
dc.subject | Proto-Oncogene Mas | - |
dc.title | Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7934-35, a region frequently affected in haematological neoplasms | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/BF00209480 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
dc.identifier.orcid | White, D. [0000-0003-4844-333X] | - |
dc.identifier.orcid | Hughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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