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https://hdl.handle.net/2440/8937
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Type: | Journal article |
Title: | N-acetylcysteine potentiates nitroglycerin-induced reversal of platelet aggregation. |
Author: | Chirkov, Y. Horowitz, J. |
Citation: | Journal of Cardiovascular Pharmacology, 1996; 28(3):375-380 |
Publisher: | LIPPINCOTT-RAVEN PUBL |
Issue Date: | 1996 |
ISSN: | 0160-2446 1533-4023 |
Abstract: | N-Acetylcysteine (N-AC) potentiates the systemic and coronary hemodynamic and antianginal effects of nitroglycerin (NGT) in humans; NTG/N-AC reduces the incidence of acute myocardial infarction in patients with unstable angina pectoris. Although previous studies have demonstrated that NTG exerts antiaggregatory effects on platelets, little information is available concerning the possible potentiation by N-AC of NTG antiplatelet effects. In the present study, we examined the in vitro effects of NTG and the combination of NTG with N-AC on reversal of ADP-induced aggregation in platelet-rich plasma (PRP) obtained from normal subjects and patients with stable angina pectoris. We also examined the potential effect of background aspirin therapy on this interaction. NTG, added to platelets 0.5 min after the beginning of aggregation, suppressed the incipient aggregation and provoked the appearance of a disaggregation phase, resulting in a concentration-dependent reversal of platelet aggregation. Platelet responsiveness to NTG was significantly less (p < 0.01) in both groups of patients (receiving and not receiving aspirin) as compared with normal subjects. N-AC (10(-5) M), which did not in itself affect aggregation, induced a threefold potentiation (p < 0.05) of the antiaggregating effect of NTG that was similar in degree for all tested groups of individuals. This potentiation of the antiplatelet effects of NTG by N-AC may contribute to the efficacy of combined NTG/N-AC therapy in patients with acute ischemic syndromes. |
Keywords: | Blood Platelets Humans Angina Pectoris Nitroglycerin Aspirin Acetylcysteine Platelet Aggregation Inhibitors Free Radical Scavengers Drug Synergism Adult Aged Middle Aged Female Male |
DOI: | 10.1097/00005344-199609000-00005 |
Published version: | http://dx.doi.org/10.1097/00005344-199609000-00005 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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