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https://hdl.handle.net/2440/89648
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Type: | Journal article |
Title: | Total synthesis of the antifungal depsipeptide petriellin A |
Author: | Sleebs, M. Scanlon, D. Karas, J. Maharani, R. Hughes, A. |
Citation: | Journal of Organic Chemistry, 2011; 76(16):6686-6693 |
Publisher: | American Chemical Society |
Issue Date: | 2011 |
ISSN: | 0022-3263 1520-6904 |
Statement of Responsibility: | Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughes |
Abstract: | We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield. |
Keywords: | Amides Peptides, Cyclic Depsipeptides Antifungal Agents Molecular Structure Cyclization |
Description: | Publication Date (Web): July 8, 2011 |
Rights: | © 2011 American Chemical Society |
DOI: | 10.1021/jo201017w |
Published version: | http://dx.doi.org/10.1021/jo201017w |
Appears in Collections: | Aurora harvest 7 Chemistry publications |
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