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https://hdl.handle.net/2440/90731
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Type: | Journal article |
Title: | Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients |
Author: | Burke, M. Morais, C. Oliver, K. Lambie, D. Gobe, G. Carroll, R. Staatz, C. Sinnya, S. Soyer, H. Winterford, C. Haass, N. Campbell, S. Isbel, N. |
Citation: | American Journal of Clinical Pathology, 2015; 143(4):514-526 |
Publisher: | Lippincott, Williams & Wilkins |
Issue Date: | 2015 |
ISSN: | 0002-9173 1943-7722 |
Statement of Responsibility: | Michael T. Burke, Christudas Morais, Kimberley A. Oliver, Duncan L. J. Lambie, Glenda C. Gobe, Robert P. Carroll, Christine E. Staatz, Sudipta Sinnya, H. Peter Soyer, Clay Winterford, Nikolas K. Haass, Scott B. Campbell and Nicole M. Isbel |
Abstract: | Objectives: This study aims to investigate how immunosuppression influences the protein expression of antiapoptotic members of the Bcl-2 family—namely, Bcl-xL and Mcl-1—in nonmelanoma skin cancer (NMSC) and the peritumoral epidermis of renal transplant recipients. Methods: NMSC and peritumoral epidermis protein expression of Bcl-xL and Mcl-1 were assessed by immunohistochemistry in renal transplant recipients receiving tacrolimus or sirolimus and the general population not receiving immunosuppression. Results: NMSC from renal transplant recipients compared with patients not receiving immunosuppressant medications had a reduced Bcl-xL expression intensity (P = .042). Mcl-1 expression intensity in NMSC was decreased in tacrolimus-treated patients compared with sirolimus-treated patients and the nonimmunosuppressed population (P = .024). Bcl-xL expression intensity was increased in peritumoral epidermis compared with NMSC (P = .002). Conclusions: It was shown for the first time that Bcl-xL and Mcl-1 expression are widespread in the peritumoral epidermis and NMSC of renal transplant recipients. Importantly in NMSC, Bcl-xL expression was reduced with immunosuppression exposure, and Mcl-1 expression was reduced in tacrolimus-treated compared with sirolimustreated patients. |
Keywords: | Humans Carcinoma, Basal Cell Carcinoma, Squamous Cell Skin Neoplasms Sirolimus Tacrolimus Immunosuppressive Agents Kidney Transplantation Immunohistochemistry Mitosis Apoptosis Adult Aged Aged, 80 and over Middle Aged Female Male bcl-X Protein Myeloid Cell Leukemia Sequence 1 Protein Transplant Recipients |
Rights: | © 2015 by The American Society for Clinical Pathology |
DOI: | 10.1309/AJCPQNB5WA3PLQBK |
Published version: | http://dx.doi.org/10.1309/ajcpqnb5wa3plqbk |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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