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https://hdl.handle.net/2440/9233
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Type: | Journal article |
Title: | Modulation of gastric motor activity by a centrally acting stimulus, circular vection, in humans |
Author: | Faas, H. Feinle-Bisset, C. Enck, P. Grundy, D. Boesiger, P. |
Citation: | American Journal of Physiology: Gastrointestinal and Liver Physiology, 2001; 280(5):G850-G857 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2001 |
ISSN: | 0193-1857 1522-1547 |
Statement of Responsibility: | Henryk Faas, Christine Feinle, Paul Enck, David Grundy, and Peter Boesiger |
Abstract: | The aims of this study were to investigate gastric motor correlates of vection, a centrally acting stimulus, and relate these responses to the induction of motion sickness symptoms. Antral contractile activity and gastric volume retained after a liquid nutrient meal (600 ml) were assessed by magnetic resonance imaging in healthy subjects during two different protocols. Vection was induced by an optokinetic drum, and subjects repeatedly rated the intensity of vection and nausea on 0–10 analog scales. Vection delayed gastric emptying {99% (89–102%) [median (interquartile ranges)] of volume retained at 28 min; control situation: 79% (69–81%), P < 0.05}. Antral contractile activity followed a distinct time course of rapid decrease [264% (272 to 259%) change from baseline activity] immediately after onset of drum rotation followed by gradual recovery upon withdrawal of the stimulus. No relationship was found between the severity of nausea and inhibition of gastric emptying or antral contractile activity. The inhibition of antral contractile activity appears to be a good measure of the peripheral response to vection but is probably independent of subjective symptom induction. |
Keywords: | illusory self motion magnetic resonance imaging |
Rights: | © 2005 by the American Physiological Society |
DOI: | 10.1152/ajpgi.2001.280.5.g850 |
Published version: | http://ajpgi.physiology.org/cgi/content/abstract/280/5/G850? |
Appears in Collections: | Aurora harvest Medicine publications |
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