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https://hdl.handle.net/2440/9235
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Type: | Journal article |
Title: | Pressure-geometry relationship in the antroduodenal region in humans |
Author: | Faas, H. Hebbard, G. Feinle-Bisset, C. Kunz, P. Brasseur, J. Indireschkumar, K. Dent, J. Boesiger, P. Thumshirn, M. Fried, M. Schwizer, W. |
Citation: | American Journal of Physiology: Gastrointestinal and Liver Physiology, 2001; 281(5):G1214-G1220 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2001 |
ISSN: | 0193-1857 1522-1547 |
Statement of Responsibility: | Henryk Faas, Geoffrey S. Hebbard, Christine Feinle, Patrik Kunz, James G. Brasseur, K. Indireshkumar, John Dent, Peter Boesiger, Miriam Thumshirn, Michael Fried, and Werner Schwizer |
Abstract: | Understanding of the control mechanisms underlying gastric motor function is still limited. The aim of the present study was to evaluate antral pressuregeometry relationships during gastric emptying slowed by intraduodenal nutrient infusion and enhanced by erythromycin. In seven healthy subjects, antral contractile activity was assessed by combined dynamic magnetic resonance imaging and antroduodenal high-resolution manometry. After intragastric administration of a 20% glucose solution (750 ml), gastric motility and emptying were recorded during intraduodenal nutrient infusion alone and, subsequently, combined with intravenous erythromycin. Before erythromycin, contraction waves were antegrade (propagation speed: 2.7 6 1.7 mm/s; lumen occlusion: 47 6 14%). Eighty-two percent (51/62) of contraction waves were detected manometrically. Fifty-four percent of contractile events (254/473) were associated with a detectable pressure event. Pressure and the degree of lumen occlusion were only weakly correlated (r2 5 0.02; P 5 0.026). After erythromycin, episodes of strong antroduodenal contractions were observed. In conclusion, antral contractions alone do not reliably predict gastric emptying. Erythromycin induces strong antroduodenal contractions not necessarily associated with fast emptying. Finally, manometry reliably detects ;80% of contraction waves, but conclusions from manometry regarding actual contractile activity must be made with care. |
Keywords: | magnetic resonance imaging manometry gastric motility erythromycin |
Rights: | © 2005 by the American Physiological Society |
DOI: | 10.1152/ajpgi.2001.281.5.g1214 |
Published version: | http://ajpgi.physiology.org/cgi/content/abstract/281/5/G1214 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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