Adelaide Research & Scholarship
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https://hdl.handle.net/2440/93028
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| Type: | Journal article |
| Title: | Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin |
| Author: | Hsieh, Y.S.Y. Taleski, D. Wilkinson, B.L. Wijeyewickrema, L.C. Adams, T.E. Pike, R.N. Payne, R.J. |
| Citation: | Chemical Communications, 2012; 48(10):1547-1549 |
| Publisher: | Royal Society of Chemistry |
| Issue Date: | 2012 |
| ISSN: | 1359-7345 1364-548X |
| Statement of Responsibility: | Yves S. Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrema, Ty E. Adams, Robert N. Pike and Richard J. Payne |
| Abstract: | Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage. |
| Rights: | © the Authors |
| DOI: | 10.1039/c1cc14773k |
| Grant ID: | http://purl.org/au-research/grants/arc/DP1094884 http://purl.org/au-research/grants/nhmrc/490900 |
| Published version: | http://dx.doi.org/10.1039/c1cc14773k |
| Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 2 |
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