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https://hdl.handle.net/2440/9330
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Type: | Journal article |
Title: | Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen |
Author: | Craddock, C. Bardy, P. Kreiter, S. Johnston, R. Apperley, J. Marks, D. Huber, C. Kolbe, K. Goulding, R. Lawler, M. Goldman, J. Hughes, T. Derigs, G. |
Citation: | British Journal of Haematology, 2000; 111(3):797-800 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2000 |
ISSN: | 0007-1048 1365-2141 |
Statement of Responsibility: | C. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derigs |
Abstract: | Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens. |
Keywords: | T-Lymphocytes Humans Leukemia Multiple Myeloma Graft vs Host Disease Lymphocyte Depletion Transplantation Conditioning Hematopoietic Stem Cell Transplantation Transplantation, Homologous Adult Aged Middle Aged Female Male |
Description: | The definitive version may be found at www.wiley.com |
Provenance: | Published Online: 2 Aug 2008 |
DOI: | 10.1111/j.1365-2141.2000.02454.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2141.2000.02454.x |
Appears in Collections: | Aurora harvest Medicine publications |
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