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https://hdl.handle.net/2440/93306
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Type: | Journal article |
Title: | Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4) |
Author: | Bosetti, C. Lucenteforte, E. Bracci, P. Negri, E. Neale, R. Risch, H. Olson, S. Gallinger, S. Miller, A. Bueno-de-Mesquita, H. Talamini, R. Polesel, J. Ghadirian, P. Baghurst, P. Zatonski, W. Fontham, E. Holly, E. Gao, Y. Yu, H. Kurtz, R. et al. |
Citation: | Annals of Oncology, 2013; 24(11):2903-2910 |
Publisher: | Oxford University Press (OUP) |
Issue Date: | 2013 |
ISSN: | 0923-7534 1569-8041 |
Statement of Responsibility: | C. Bosetti, E. Lucenteforte, P. M. Bracci, E. Negri, R. E. Neale, H. A. Risch, S. H. Olson, S. Gallinger, A. B. Miller, H. B. Bueno-de-Mesquita, R. Talamini, J. Polesel, P. Ghadirian, P. A. Baghurst, W. Zatonski, E. Fontham, E. A. Holly, Y. T. Gao, H. Yu, R. C. Kurtz, M. Cotterchio, P. Maisonneuve, M. P. Zeegers, E. J. Duell, P. Boffetta and C. La Vecchia |
Abstract: | BACKGROUND: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. METHODS: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. RESULTS: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. CONCLUSIONS: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance. |
Keywords: | Pancreatic Neoplasms Gastrointestinal Diseases Case-Control Studies Gastrectomy Logistic Models Risk Factors |
Rights: | © The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com |
DOI: | 10.1093/annonc/mdt336 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/442302 |
Published version: | http://dx.doi.org/10.1093/annonc/mdt336 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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