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https://hdl.handle.net/2440/93562
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Type: | Conference item |
Title: | The fatty-acid composition of brain, retina and erythrocytes in breast and formula-fed infants |
Author: | Makrides, M. Neumann, M. Byard, R. Simmer, K. Gibson, R. |
Citation: | Pediatric Research, 1995, vol.37, iss.4, pp.A127-A127 |
Publisher: | Williams & Wilkins |
Issue Date: | 1995 |
ISSN: | 0031-3998 |
Conference Name: | The American Pediatric Society and The Society for Pediatric Research Annual Meeting (7 May 1995 - 11 May 1995 : San Diego, California) |
Statement of Responsibility: | Maria Makrides, Mark Neumann, Roger Byard, Karen Simmer, Robert Gibson |
Abstract: | Breast-fed infants score better on visual and developmental tests than do formula-fed infants and this has been related to higher concentrations of erythrocyte docosahexaenoic acid (DHA, 22:6 omega 3). This prompted an investigation into the relationship between brain, retina, and erythrocyte fatty acids and diet in infancy. Total lipids of erythrocytes, retina, and brain cortex from 35 term infants were analyzed by capillary gas chromatography. Breast-fed infants had a greater proportion of DHA in their erythrocytes and brain cortex relative to those fed formula (P < 0.005) but differences were not observed in retina. Cortex DHA increased in breast-fed (but not formula-fed) infants with age (r2 = 0.72, P < 0.01, n = 15), largely an effect of length of feeding (r2 = 0.62, P < 0.01, n = 35). There was an association between age at death and erythrocyte DHA with cortex DHA (r2 = 0.50, P < 0.01). In contrast, accretion of cortex arachidonic acid was dependent on age but not diet. The higher concentration of DHA in brains of breast-fed infants may explain the improved neurodevelopment reported in breast-fed compared with formula-fed infants. |
Keywords: | Cerebral Cortex Retina Erythrocytes Humans alpha-Linolenic Acid Docosahexaenoic Acids Fatty Acids, Unsaturated Arachidonic Acid Linoleic Acids Linoleic Acid Bottle Feeding Regression Analysis Breast Feeding Infant Food Infant Infant, Newborn Female Male |
Rights: | Copyright status unknown |
DOI: | 10.1093/ajcn/60.2.189 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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