Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/93586
Type: | Journal article |
Title: | Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition |
Author: | Makrides, M. Neumann, M. Gibson, R. |
Citation: | European Journal of Clinical Nutrition, 1996; 50(6):352-357 |
Publisher: | Nature Publishing Group |
Issue Date: | 1996 |
ISSN: | 0954-3007 1476-5640 |
Statement of Responsibility: | Makrides M, Neumann MA, Gibson RA. |
Abstract: | OBJECTIVE: To assess the effect of varying maternal intake of docosahexaenoic acid (DHA, 22 : 6n-3), in the absence of other dietary polyunsaturates, on breast milk fatty acids. DESIGN AND INTERVENTION: Lactating mothers were randomised on day 5 post-partum to groups consuming equal numbers of capsules but containing either placebo or an oil containing DHA (43%) as its only polyunsaturate to receive 0, 0.2, 0.4, 0.9, 1.3 g DHA/day. Breast milk fatty acids as well as maternal plasma and erythrocyte phospholipids were assessed at 12 weeks post partum by capillary gas chromatography. RESULTS: Breast milk DHA levels ranged from 0.2 to 1.7% of total fatty acids and increased in a dose dependent manner (r2 = 0.89, P < 0.01). Maternal plasma (r2 = 0.71, P < 0.01) and erythrocyte (r2 = 0.77, P < 0.01) phospholipid DHA levels increased and were also strongly associated with dietary dose of DHA. Increasing maternal dietary doses of DHA did not affect breast milk arachidonic acid (AA, 20 : 4n-6) levels or antioxidant status as measured by plasma vitamin A or E levels. CONCLUSIONS: Our results have demonstrated that DHA in the diet has a strong, specific and dose-dependent effect on breast milk DHA. |
Keywords: | Dose-Response Relationship, Drug |
Rights: | Copyright status unknown |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 2 |
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