Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9400
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chew, S. | - |
dc.contributor.author | Akdemir, F. | - |
dc.contributor.author | Chen, P. | - |
dc.contributor.author | Lu, W. | - |
dc.contributor.author | Mills, K. | - |
dc.contributor.author | Daish, T. | - |
dc.contributor.author | Kumar, S. | - |
dc.contributor.author | Rodriguez, A. | - |
dc.contributor.author | Abrams, J. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Developmental Cell, 2004; 7(6):897-907 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.issn | 1878-1551 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9400 | - |
dc.description.abstract | Among the seven caspases encoded in the fly genome, only dronc contains a caspase recruitment domain. To assess the function of this gene in development, we produced a null mutation in dronc. Animals lacking zygotic dronc are defective for programmed cell death (PCD) and arrest as early pupae. These mutants present a range of defects, including extensive hyperplasia of hematopoietic tissues, supernumerary neuronal cells, and head involution failure. dronc genetically interacts with the Ced4/Apaf1 counterpart, Dark, and adult structures lacking dronc are disrupted for fine patterning. Furthermore, in diverse models of metabolic injury, dronc− cells are completely insensitive to induction of cell killing. These findings establish dronc as an essential regulator of cell number in development and illustrate broad requirements for this apical caspase in adaptive responses during stress-induced apoptosis. | - |
dc.description.statementofresponsibility | Su Kit Chew, Fatih Akdemir, Po Chen, Wan-Jin Lu, Kathryn Mills, Tasman Daish, Sharad Kumar, Antony Rodriguez and John M. Abrams | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.source.uri | http://www.developmentalcell.com/ | - |
dc.subject | Eye | - |
dc.subject | Hemocytes | - |
dc.subject | Animals | - |
dc.subject | Drosophila melanogaster | - |
dc.subject | Caspases | - |
dc.subject | Drosophila Proteins | - |
dc.subject | Green Fluorescent Proteins | - |
dc.subject | RNA, Messenger | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Genetic Complementation Test | - |
dc.subject | In Situ Nick-End Labeling | - |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject | Cell Death | - |
dc.subject | Apoptosis | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Mutagenesis | - |
dc.subject | Body Patterning | - |
dc.subject | Genotype | - |
dc.subject | Homozygote | - |
dc.subject | Mutation | - |
dc.subject | Alleles | - |
dc.subject | Genome | - |
dc.subject | Models, Genetic | - |
dc.subject | Time Factors | - |
dc.subject | Image Processing, Computer-Assisted | - |
dc.title | The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.devcel.2004.09.016 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.