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https://hdl.handle.net/2440/94022
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dc.contributor.author | Aw, M. | - |
dc.contributor.author | Simovic, S. | - |
dc.contributor.author | Addai-Mensah, J. | - |
dc.contributor.author | Losic, D. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Nanomedicine, 2011; 6(7):1159-1173 | - |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.issn | 1748-6963 | - |
dc.identifier.uri | http://hdl.handle.net/2440/94022 | - |
dc.description.abstract | Aim: This study explores the use of natural silica-based porous material from diatoms, known as diatomaceous earth, as a drug carrier of therapeutics for implant- and oral-delivery applications. Materials & Methods: To prove this concept, two drugs models were used and investigated: a hydrophobic (indomethacin) and hydrophilic (gentamicin). Results & Discussion: Results show the effectiveness of diatom microcapsules for drug-delivery application, showing 14–22 wt% drug loading capacity and sustained drug release over 2 weeks. Two steps in the drug release from diatom structures were observed: the first, rapid release (over 6 h is attributed to the surface deposited drug) and the second, slow and sustained release over 2 weeks with zero order kinetics. Conclusion: These results confirm that natural material based on diatom silica can be successfully applied as a drug carrier for both oral and implant drug-delivery applications, offering considerable potential to replace existing synthetic nanomaterials. | - |
dc.description.statementofresponsibility | Moom Sinn Aw, Spomenka Simovic, Jonas Addai-Mensah & Dusan Losic | - |
dc.language.iso | en | - |
dc.publisher | Future Medicine | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.2217/nnm.11.29 | - |
dc.subject | Diatoms | - |
dc.subject | Silicon Dioxide | - |
dc.subject | Indomethacin | - |
dc.subject | Gentamicins | - |
dc.subject | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject | Capsules | - |
dc.subject | Drug Carriers | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Porosity | - |
dc.title | Silica microcapsules from diatoms as new carrier for delivery of therapeutics | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2217/nnm.11.29 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/LP0989229 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Losic, D. [0000-0002-1930-072X] | - |
Appears in Collections: | Aurora harvest 2 Chemical Engineering publications |
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