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https://hdl.handle.net/2440/9410
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dc.contributor.author | Russo, A. | - |
dc.contributor.author | Botten, R. | - |
dc.contributor.author | Kong, M. | - |
dc.contributor.author | Chapman, I. | - |
dc.contributor.author | Fraser, R. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Sunt, W. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Diabetic Medicine, 2004; 21(2):176-182 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.issn | 1464-5491 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9410 | - |
dc.description | © 2004 Diabetes UK. Diabetic Medicine. The definitive version is available at www.blackwell-synergy.com | - |
dc.description.abstract | <h4>Aims</h4>To determine the effects of acute hyperglycaemia on anorectal motor and sensory function in patients with diabetes mellitus.<h4>Methods</h4>In eight patients with Type 1, and 10 patients with Type 2 diabetes anorectal motility and sensation were evaluated on separate days while the blood glucose concentration was stabilized at either 5 mmol/l or 12 mmol/l using a glucose clamp technique. Eight healthy subjects were studied under euglycaemic conditions. Anorectal motor and sensory function was evaluated using a sleeve/sidehole catheter, incorporating a barostat bag.<h4>Results</h4>In diabetic subjects hyperglycaemia was associated with reductions in maximal (P<0.05) and plateau (P<0.05) anal squeeze pressures and the rectal pressure/volume relationship (compliance) during barostat distension (P<0.01). Hyperglycaemia had no effect on the perception of rectal distension. Apart from a reduction in rectal compliance (P<0.01) and a trend (P=0.06) for an increased number of spontaneous anal sphincter relaxations, there were no differences between the patients studied during euglycaemia when compared with healthy subjects.<h4>Conclusions</h4>In patients with diabetes, acute hyperglycaemia inhibits external anal sphincter function and decreases rectal compliance, potentially increasing the risk of faecal incontinence. | - |
dc.description.statementofresponsibility | A. Russo, R. Botten, M.-F. Kong, I. M. Chapman, R. J. L. Fraser, M. Horowitz and W.-M. Sun | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1464-5491.2004.01106.x | - |
dc.subject | anorectal motility | - |
dc.subject | hyperglycaemia | - |
dc.subject | faecal incontinence | - |
dc.title | Effects of acute hyperglycaemia on anorectal motor and sensory function in diabetes mellitus | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1464-5491.2004.01106 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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