Adelaide Research & Scholarship
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https://hdl.handle.net/2440/94719
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| Type: | Journal article |
| Title: | TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice |
| Author: | Kentish, S. Frisby, C. Kritas, S. Li, H. Hatzinikolas, G. O'Donnell, T. Wittert, G. Page, A. |
| Citation: | PLoS One, 2015; 10(8):e0135892-1-e0135892-15 |
| Publisher: | Public Library of Science |
| Issue Date: | 2015 |
| ISSN: | 1932-6203 1932-6203 |
| Editor: | Cota, D. |
| Statement of Responsibility: | Stephen J. Kentish, Claudine L. Frisby, Stamatiki Kritas, Hui Li, George Hatzinikolas, Tracey A. O, Donnell, Gary A. Wittert, Amanda J. Page |
| Abstract: | Within the gastrointestinal tract vagal afferents play a role in control of food intake and satiety signalling. Activation of mechanosensitive gastric vagal afferents induces satiety. However, gastric vagal afferent responses to mechanical stretch are reduced in high fat diet mice. Transient receptor potential vanilloid 1 channels (TRPV1) are expressed in vagal afferents and knockout of TRPV1 reduces gastro-oesophageal vagal afferent responses to stretch. We aimed to determine the role of TRPV1 on gastric vagal afferent mechanosensitivity and food intake in lean and HFD-induced obese mice. |
| Keywords: | Esophagus Stomach Vagus Nerve Adipose Tissue Animals Mice, Inbred C57BL Mice Mice, Obese Obesity Body Weight Signal Transduction Mechanotransduction, Cellular Eating Male TRPV Cation Channels Gene Knockout Techniques Diet, High-Fat |
| Rights: | © 2015 Kentish et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| DOI: | 10.1371/journal.pone.0135892 |
| Published version: | http://dx.doi.org/10.1371/journal.pone.0135892 |
| Appears in Collections: | Aurora harvest 7 Medicine publications |
Files in This Item:
| File | Description | Size | Format | |
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| hdl_94719.pdf | Published version | 892.94 kB | Adobe PDF | View/Open |
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