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https://hdl.handle.net/2440/95379
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Type: | Journal article |
Title: | Morphological variation of the maxillary lateral incisor |
Author: | Kondo, S. Townsend, G. Matsuno, M. |
Citation: | Japanese Dental Science Review, 2014; 50(4):100-107 |
Publisher: | Japanese Association for Dental Science |
Issue Date: | 2014 |
ISSN: | 1882-7616 2213-6851 |
Statement of Responsibility: | Shintaro Kondo, Grant Townsend, Masanobu Matsuno |
Abstract: | The maxillary lateral incisor is a variable tooth morphologically. This tooth frequently shows reduction in size, and also various alterations in shape, for example, peg-shaped, cone-shaped, barrel-shaped and canine-shaped. The lateral incisor variant can be analyzed by family studies and using twin models, and these approaches have shown that genetic, epigenetic and environmental factors can all contribute to variation in the trait. Discordance of the phenotype in monozygotic twin pairs could be explained by the following two hypotheses: (1) the embryological environment of monochorionic twin pairs who share the same placenta and chorionic membrane during the prenatal period may differ, (2) phenotypic variation may be caused by epigenetic influences. Possible developmental factors are discussed in this review. Recent studies suggest that Msx1, Pax9 and Axin2 genes predispose to lateral incisor agenesis. Tooth reduction and agenesis seem to represent inter-related complex multifactorial traits, influenced by a combination of gene expression and function, environmental interaction and developing timing. Thus, accumulation of large data banks of morphological data is needed to support and clarify ongoing molecular genetic studies of dental development. |
Keywords: | Twin model; genetic factors; environmental factors; epigenetics; compensatory interactions; inhibitory cascade |
Rights: | © 2014 Japanese Association for Dental Science. Published by Elsevier Ltd. Open access under CC BY-NC-ND license. |
DOI: | 10.1016/j.jdsr.2014.06.002 |
Published version: | http://dx.doi.org/10.1016/j.jdsr.2014.06.002 |
Appears in Collections: | Aurora harvest 3 Dentistry publications |
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hdl_95379.pdf | Published version | 1.12 MB | Adobe PDF | View/Open |
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