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https://hdl.handle.net/2440/95431
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dc.contributor.author | Morris, H. | - |
dc.contributor.author | Turner, A. | - |
dc.contributor.author | Anderson, P. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Frontiers in Bioscience (Elite Edition), 2012; E4(2):677-689 | - |
dc.identifier.issn | 1945-0494 | - |
dc.identifier.issn | 1945-0508 | - |
dc.identifier.uri | http://hdl.handle.net/2440/95431 | - |
dc.description.abstract | Vitamin D status relates to two bone diseases, osteomalacia and osteoporosis which arise from distinct pathophysiogical pathways. They can occur in children as well as adults. Osteomalacia or rickets arises from a delay in mineralization and can be caused by severe vitamin D deficiency where the key to curing osteomalacia is the endocrine action of circulating 1,25-dihydroxyvitamin D to normalize the active intestinal transport of calcium and phosphate. Osteoporosis or sub-optimal bone mineral accretion during growth is a risk factor for fracture in children. Current evidence suggests serum 25- hydroxyvitamin D levels between 20 and 80 nmol/L are associated with decreased bone mineral content as a result, at least partly, of reduced vitamin D metabolism and activity within bone cells. The local synthesis of 1,25- dihydroxyvitamin D within bone is necessary to modulate bone resorption and promote bone formation. Thus an adequate vitamin D status is necessary for vitamin D activity within bone to establish a healthy skeleton. | - |
dc.description.statementofresponsibility | Howard A Morris, Andrew G Turner, Paul H Anderson | - |
dc.language.iso | en | - |
dc.publisher | Frontiers in Bioscience | - |
dc.rights | Copyright © Frontiers in Bioscience | - |
dc.source.uri | https://www.bioscience.org/2012/v4e/af/409/fulltext.htm | - |
dc.subject | Vitamin D metabolism; CYP27B1; CYP 24; bone cell activities; osteomalacia; osteoporosis; vitamin D actvities; review | - |
dc.title | Vitamin-D regulation of bone mineralization and remodelling during growth | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2741/409 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Morris, H. [0000-0002-2745-3750] | - |
dc.identifier.orcid | Anderson, P. [0000-0002-8685-3252] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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