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https://hdl.handle.net/2440/9547
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Type: | Journal article |
Title: | An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in drosophila cells |
Author: | Cakouros, D. Daish, T. Mills, K. Kumar, S. |
Citation: | Journal of Biological Chemistry, 2004; 279(18):18467-18471 |
Publisher: | Amer Soc Biochemistry Molecular Biology Inc |
Issue Date: | 2004 |
ISSN: | 0021-9258 1083-351X |
Statement of Responsibility: | Dimitrios Cakouros, Tasman J. Daish, Kathryn Mills, and Sharad Kumar |
Abstract: | Developmentally programmed cell death is regulated by a balance between pro- and anti-death signaling. During Drosophila metamorphosis, the removal of larval tissues is dependent on the steroid hormone ecdys one, which controls the levels of pro- and anti-death molecules. Ecdysone binds to its heterodimeric receptor ecdysone receptor/ultraspiracle to mediate transcription of primary response genes. Here we show that CARMER, an arginine-histone methyltransferase, is critical in coordinating ecdysone-induced expression of Drosophila cell death genes. Ablation of CARMER blocks ecdysone-induced cell death in Drosophila cells, but not apoptosis induced by cell stress. We demonstrate that CARMER associates with the ecdysone receptor complex and modulates the ecdysoneinduced transcription of a number of apoptotic genes. Thus, the chromatin-modifying protein, CARMER, modulates cell death by controlling the hormone-dependent expression of the core cell death machinery. |
Keywords: | Animals Drosophila Ecdysone Receptors, Steroid RNA, Messenger Sequence Alignment Apoptosis Transcription, Genetic Gene Expression Regulation, Developmental Amino Acid Sequence Protein-Arginine N-Methyltransferases |
Description: | © 2004 The American Society for Biochemistry and Molecular Biology |
DOI: | 10.1074/jbc.M400972200 |
Published version: | http://dx.doi.org/10.1074/jbc.m400972200 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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