Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9563
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Type: | Journal article |
Title: | Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high-risk subjects |
Author: | Clifton, P. |
Citation: | BioMed Research International, 2004; 5(5):272-278 |
Publisher: | Hindawi Publishing Corporation |
Issue Date: | 2004 |
ISSN: | 1110-7243 1110-7251 |
Statement of Responsibility: | Peter M. Clifton |
Abstract: | Grape seed extract (GSE) has in vitro antioxidant activity but whether or not it works in vivo is not clear. In a fully randomised, crossover trial with 4-week treatment periods on 36 men and women with above-average vascular risk, we aimed to demonstrate that 2 g/day of GSE (1 g of polyphenols) alone, or with 1 g/day of added quercetin in yoghurt, favourably alters vascular function, endothelial function, and degree of oxidative damage in comparison to a control yoghurt. GSE alone improved flow-mediated dilatation determined ultrasonically by an absolute 1.1% compared with control. There was no effect of the combination of GSE with quercetin. No other blood or urine measure was altered. Thus sufficient polyphenols from GSE appear to be absorbed to influence endothelial nitric oxide production, and GSE has the potential to favourably influence vascular function. |
Description: | Copyright © 2008 Hindawi Publishing Corporation. |
DOI: | 10.1155/S1110724304403088 |
Published version: | http://dx.doi.org/10.1155/s1110724304403088 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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File | Description | Size | Format | |
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hdl_9563.pdf | Published version | 509.42 kB | Publisher's PDF | View/Open |
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