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https://hdl.handle.net/2440/96519
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Type: | Journal article |
Title: | Histamine H₄ receptors in the gastrointestinal tract |
Other Titles: | Histamine H(4) receptors in the gastrointestinal tract |
Author: | Deiteren, A. De Man, J. Pelckmans, P. De Winter, B. |
Citation: | British Journal of Pharmacology, 2015; 172(5):1165-1178 |
Publisher: | Wiley |
Issue Date: | 2015 |
ISSN: | 0007-1188 1476-5381 |
Statement of Responsibility: | A Deiteren, J G De Man, P A Pelckmans and B Y De Winter |
Abstract: | Histamine is a well-established mediator involved in a variety of physiological and pathophysiological mechanisms and exerts its effect through activation of four histamine receptors (H₁-H₄). The histamine H₄ receptor is the newest member of this histamine receptor family, and is expressed throughout the gastrointestinal tract as well as in the liver, pancreas and bile ducts. Functional studies using a combination of selective and non-selective H₄ receptor ligands have rapidly increased our knowledge of H₄ receptor involvement in gastrointestinal processes both under physiological conditions and in models of disease. Strong evidence points towards a role for H₄ receptors in the modulation of immune-mediated responses in gut inflammation such as in colitis, ischaemia/reperfusion injury, radiation-induced enteropathy and allergic gut reactions. In addition, data have emerged implicating H₄ receptors in gastrointestinal cancerogenesis, sensory signalling, and visceral pain as well as in gastric ulceration. These studies highlight the potential of H₄ receptor targeted therapy in the treatment of various gastrointestinal disorders such as inflammatory bowel disease, irritable bowel syndrome and cancer. |
Keywords: | Gastrointestinal Tract Animals Humans Receptors, Histamine |
Rights: | © 2014 The British Pharmacological Society |
DOI: | 10.1111/bph.12989 |
Published version: | http://dx.doi.org/10.1111/bph.12989 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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