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https://hdl.handle.net/2440/9675
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Type: | Journal article |
Title: | Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia |
Author: | Ferrao, P. Sincock, Paul Cole, Stephen R. Ashman, Leonie Kay |
Citation: | Leukemia Research. 25:395-405 |
Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
Issue Date: | 2001 |
ISSN: | 0145-2126 |
School/Discipline: | School of Medicine |
Organisation: | Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science |
Abstract: | Drug compartmentalization as well as drug efflux can contribute to drug resistance. We demonstrate the presence of P-gp in intracellular vesicles in certain AML cell lines and show localization of DNR to a similar subcellular compartment(s) that can be altered in the presence of P-gp inhibitors. Analysis of leukaemic cell lines and 50 AML patient samples showed that the level of P-gp mRNA or total P-gp protein correlated better with drug efflux than surface P-gp protein, suggesting that intracellular P-gp may contribute to MDR in AML. Therefore, the level of total P-gp protein or mRNA may be a better indicator of MDR than surface P-gp protein. In addition, we provide evidence for a novel mechanism of drug sequestration in K562 myeloid leukaemic cells. |
DOI: | 10.1016/S0145-2126(00)00156-9 |
Appears in Collections: | Medicine publications |
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