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https://hdl.handle.net/2440/9712
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Type: | Journal article |
Title: | Human duodenal phase III migrating motor complex activity is predominantly antegrade, as revealed by high-resolution manometry and colour pressure plots |
Author: | Andrews, J. O'Donovan, D. Hebbard, G. Malbert, C. Doran, S. Dent, J. |
Citation: | Neurogastroenterology and Motility, 2002; 14(4):331-338 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2002 |
ISSN: | 1350-1925 1365-2982 |
Abstract: | Abstract Late phase III migrating motor complex activity has been said to be primarily retroperistaltic but has not been assessed with high resolution manometry or three-dimensional colour pressure plots (pressure/time/distance). Duodenal phase III was examined in healthy young volunteers (seven male, two female) with a 20-lumen assembly. With the most proximal sidehole in the distal antrum, after a 4.5-cm interval 18 sideholes at 1.5-cm intervals spanned the duodenum with a final sidehole 3 cm beyond. Fasting pressures were recorded until phase III occurred. Comparisons were made between proximal (P) and distal (D) duodenum during early (E) (first 0.5-1 min) and late (L) (last 0.5-1 min) phase III. With colour pressure analysis, 121 of 180 pressure wave (PW) sequences were purely antegrade, two purely retrograde and 57 bidirectional. Ten of fifty-seven bidirectional PW sequences were complex, branching to become two separate sequences. Bidirectional sequences occurred more frequently in late than early phase III (L 43 vs. E 14 of 57), but their occurrence did not differ between proximal and distal duodenum (P31 vs. D 24 of 57). Antegrade propagation velocity was faster in late compared with early phase III (L 28.50 vs. E 17.05 mm s(-1); P = 0.006), but did not differ between proximal and distal duodenum. Colour pressure analysis also indicated an intermittent segmental pattern to phase III, with each subject exhibiting a change in velocity or direction, or a relative failure of peristalsis somewhere along the duodenum during part of phase III. Duodenal phase III is not homogenous and, in contrast with previous studies, does not primarily constitute a retroperistaltic pump. Colour pressure analysis is useful in interpreting intraluminal pressure profiles and may improve the sensitivity and specificity of clinical studies. |
Keywords: | Duodenum Humans Chi-Square Distribution Manometry Myoelectric Complex, Migrating Peristalsis Pressure Adult Female Male |
DOI: | 10.1046/j.1365-2982.2002.00337.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2982.2002.00337.x |
Appears in Collections: | Aurora harvest Medicine publications |
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