Fas gene promoter polymorphisms in primary Sjogren's syndrome

Abstract

<h4>Background</h4>Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS).<h4>Objective</h4>To examine genetic variation in the promoter region of the Fas gene in pSS.<h4>Methods</h4>Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls.<h4>Results</h4>No significant differences in allele or genotype frequencies were detected between the patients with pSS and controls. However, significant associations were observed with Ro/La autoantibody negative patients, who display milder and later onset disease. The -670A allele was more frequent in Ro/La autoantibody negative patients than in Ro/La autoantibody positive patients (p = 0.04).<h4>Conclusion</h4>This study does not confirm an earlier report of an association between pSS and the Fas promoter -670G allele. However, the results suggest that genetically determined variability in Fas expression may modulate Ro/La autoantibody responses in patients with pSS.