Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9824
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Milton, A. | - |
dc.contributor.author | Zalewski, P. | - |
dc.contributor.author | Ratnaike, R. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Biometals, 2004; 17(6):707-713 | - |
dc.identifier.issn | 0966-0844 | - |
dc.identifier.issn | 1572-8773 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9824 | - |
dc.description | The original publication is available at www.springerlink.com | - |
dc.description.abstract | Acute and chronic arsenic exposure results in toxicity in humans and causes many neurological and other manifestations. For the first time the present study reports that zinc decreases arsenic-induced apoptosis and also confirms a single report of apoptosis induced by arsenic in a neuronal cell line. Apoptosis measured by DEVD-caspase activity peaked between 10 M and 20 M of arsenic trioxide. Higher concentrations of arsenic up to 40 M caused increasing cell death with diminishing DEVD-caspase activity. The beneficial effect of zinc was proportional to its concentration with a significant decrease in arsenic-induced DEVD-caspase activity at 50 M and 75 M zinc (P<0.05). This finding may be of therapeutic benefit in people suffering from chronic exposure to arsenic from natural sources, a global problem especially relevant to millions of people on the Indian subcontinent. | - |
dc.description.statementofresponsibility | Austin Graham Milton, Peter David Zalewski and Ranjit Nihal Ratnaike | - |
dc.language.iso | en | - |
dc.publisher | Kluwer Academic Publ | - |
dc.source.uri | http://dx.doi.org/10.1007/s10534-004-1210-3 | - |
dc.subject | Neurons | - |
dc.subject | Cell Line | - |
dc.subject | Animals | - |
dc.subject | Mice | - |
dc.subject | Arsenicals | - |
dc.subject | Oxides | - |
dc.subject | Zinc | - |
dc.subject | Zinc Sulfate | - |
dc.subject | Sodium Oxybate | - |
dc.subject | Caspases | - |
dc.subject | Enzyme Inhibitors | - |
dc.subject | Apoptosis | - |
dc.subject | Enzyme Activation | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Phenotype | - |
dc.subject | Time Factors | - |
dc.subject | Arsenic Trioxide | - |
dc.title | Zinc protects against arsenic induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10534-004-1210-3 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Zalewski, P. [0000-0001-5196-2611] | - |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.