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https://hdl.handle.net/2440/99973
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Type: | Journal article |
Title: | Quatsomes for the treatment of Staphylococcus aureus biofilm |
Author: | Thomas, N. Dong, D. Richter, K. Ramezanpour, M. Vreugde, S. Thierry, B. Wormald, P. Prestidge, C. |
Citation: | Journal of Materials Chemistry B, 2015; 3(14):2770-2777 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2015 |
ISSN: | 2050-7518 2050-750X |
Statement of Responsibility: | Nicky Thomas, Dong Dong, Katharina Richter, Mahnaz Ramezanpour, Sarah Vreugde, Benjamin Thierry, Peter-John Wormald and Clive A. Prestidge |
Abstract: | The anti-biofilm effect of drug delivery systems composed of the antiseptic quaternary ammonium compound cetylpyridinium chloride (CPC) and cholesterol was evaluated in Staphylococcus aureus biofilm. Self-assembly of CPC/cholesterol to approximately 100 nm CPC-quatsomes was successfully accomplished by a simple sonication/dispersion method over a broad concentration range from 0.5 to 10 mg ml−1 CPC. CPC-quatsomes showed a dose-dependent anti-biofilm effect, killing >99% of biofilm-associated S. aureus from 5% mg ml−1 after 10 minutes exposure. Cell toxicity studies with CPC-quatsomes in Nuli-1 cells revealed no adverse effects at all tested CPC concentrations. CPC-quatsomes, therefore, have a promising potential as novel drug delivery systems with “built-in” anti-biofilm activity. |
Rights: | This journal is © The Royal Society of Chemistry 2015 |
DOI: | 10.1039/c4tb01953a |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1047576 http://purl.org/au-research/grants/nhmrc/1090898 |
Published version: | http://dx.doi.org/10.1039/c4tb01953a |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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