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https://hdl.handle.net/2440/113410
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Type: | Journal article |
Title: | Keyhole limpet haemocyanin - A model antigen for human immunotoxicological studies |
Author: | Swaminathan, A. Lucas, R.M. Dear, K. McMichael, A.J. |
Citation: | British Journal of Clinical Pharmacology, 2014; 78(5):1135-1142 |
Publisher: | British Pharmacological Society Journals |
Issue Date: | 2014 |
ISSN: | 0306-5251 1365-2125 |
Statement of Responsibility: | Ashwin Swaminathan, Robyn M. Lucas, Keith Dear & Anthony J. McMichael |
Abstract: | Immunization with a T-cell dependent antigen has been promoted as a reliable and sensitive tool for assessing the influence of putative immunotoxic exposures or agents on immune function. Keyhole limpet haemocyanin (KLH) is a very large, copper-containing protein molecule derived from the haemolymph of the inedible mollusc, Megathura crenulata. KLH is a highly immunogenic T-cell dependent antigen that is used increasingly in immunotoxicological studies, particularly in those involving animals. This report systematically reviews the human clinical studies that have used trans-cutaneous KLH immunization for assessment of the influence of various physiological and disease states and exposures on immune function over the last 20 years (1994-2013). These studies varied in their immunization protocols, formulation of KLH, dose, site and route of administration and immunoassay platforms developed to assess KLH-specific responses. KLH immunization has been well tolerated with only mild to moderate adverse effects reported. Though very promising as a model antigen candidate in immunotoxicology research, more work on standardizing immunization and immunoassay protocols is required. |
Keywords: | Clinical studies Immunization Immunotoxicology Keyhole limpet haemocyanin KLH |
Rights: | © 2014 The British Pharmacological Society |
DOI: | 10.1111/bcp.12422 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/585489 |
Published version: | http://dx.doi.org/10.1111/bcp.12422 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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