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https://hdl.handle.net/2440/128772
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Type: | Journal article |
Title: | Hydrogel-based preparation of cell aggregates for biomedical applications |
Author: | Zhang, J. Yun, S. Du, Y. Zannettino, A. Zhang, H. |
Citation: | Applied Materials Today, 2020; 20:100747-1-100747-19 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 2352-9407 2352-9407 |
Statement of Responsibility: | Jiabin Zhang, Seonho Yun, Yuguang Du, Andrew Zannettino, Hu Zhang |
Abstract: | Cell aggregates are widely used either as in-vitro models for drug screening, fundamental studies on disease progression and developmental biology, as well as in-vivo injectable cells for tissue regeneration. Compared to single-cell suspensions, cell aggregates retain superior cell viability, mimic in-vivo microenvironments and enhance functional properties, such as superior anti-inflammatory properties of mesenchymal stem/stromal cell aggregates or enhanced albumin production by hepatocyte aggregates. Cell aggregates can be either prepared by conventional spontaneous aggregation, or advanced substrate-based and technology-assisted methods, which have been well described in previous reviews. However, hydrogel-based preparation of cell aggregates is a novel, hitherto rarely considered method compared to conventional preparation of cell aggregates, such as hanging drops and commercial AggreWell™ plates. This review will mainly focus on two-dimensional (2D) hydrogel surface -based and three-dimensional (3D) hydrogel embedding-based preparation of cell aggregates by revealing the underlying mechanisms and highlighting some of their potential biomedical applications. |
Keywords: | 2D; 3D; hydrogel; cell aggregate; biomedical application |
Rights: | © 2020 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.apmt.2020.100747 |
Grant ID: | http://purl.org/au-research/grants/arc/DP160104632 |
Published version: | http://dx.doi.org/10.1016/j.apmt.2020.100747 |
Appears in Collections: | Aurora harvest 8 Chemical Engineering publications |
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