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https://hdl.handle.net/2440/131571
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Type: | Book chapter |
Title: | Drosophila as a model to understand autophagy deregulation in human disorders |
Author: | Denton, D. O'Keefe, L. Kumar, S. |
Citation: | Progress in Molecular Biology and Translational Science, 2020 / Martinez, A.B., Galluzzi, L. (ed./s), vol.172, Ch.15, pp.375-409 |
Publisher: | Academic Press |
Publisher Place: | Cambridge, MA; United States |
Issue Date: | 2020 |
Series/Report no.: | Progress in Molecular Biology and Translational Science |
ISBN: | 9780128220214 |
Editor: | Martinez, A.B. Galluzzi, L. |
Statement of Responsibility: | Donna Denton, Louise O'Keefe, Sharad Kumar |
Abstract: | Autophagy has important functions in normal physiology to maintain homeostasis and protect against cellular stresses by the removal of harmful cargos such as dysfunctional organelles, protein aggregates and invading pathogens. The deregulation of autophagy is a hallmark of many diseases and therapeutic targeting of autophagy is highly topical. With the complex role of autophagy in disease it is essential to understand the genetic and molecular basis of the contribution of autophagy to pathogenesis. The model organism, Drosophila, provides a genetically amenable system to dissect out the contribution of autophagy to human disease models. Here we review the roles of autophagy in human disease and how autophagy studies in Drosophila have contributed to the understanding of pathophysiology. |
Keywords: | Animals Humans Drosophila melanogaster Neoplasms Cell Transformation, Neoplastic Neurodegenerative Diseases Lysosomal Storage Diseases Disease Models, Animal Cachexia Drosophila Proteins Tumor Suppressor Proteins Drug Screening Assays, Antitumor Organ Specificity DNA Repeat Expansion Conserved Sequence Homeostasis Mutation Mosaicism Autophagy Neoplastic Stem Cells Drug Discovery Imaginal Discs Autophagy-Related Proteins Infections |
Rights: | © 2020 Elsevier. All rights reserved. |
DOI: | 10.1016/bs.pmbts.2020.01.005 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1124490 http://purl.org/au-research/grants/nhmrc/1103006 http://purl.org/au-research/grants/arc/DP170100623 |
Published version: | https://www.sciencedirect.com/bookseries/progress-in-molecular-biology-and-translational-science/vol/172/suppl/C |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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