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https://hdl.handle.net/2440/133507
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Type: | Journal article |
Title: | Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release |
Author: | Yu, L. Sun, Q. Hui, Y. Seth, A. Petrovsky, N. Zhao, C.X. |
Citation: | Journal of Colloid and Interface Science, 2019; 539:497-503 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0021-9797 1095-7103 |
Statement of Responsibility: | Lei Yu, Qi Sun, Yue Hui, Arjun Seth, Nikolai Petrovsky, Chun-Xia Zhao |
Abstract: | Alginate hydrogel particles are promising delivery systems for protein encapsulation and controlled release because of their excellent biocompatibility, biodegradability, and mild gelation process. In this study, a facile microfluidic approach is developed for making uniform core-shell hydrogel microparticles. To address the challenge of protein retention within the alginate gel matrix, poly(ethyleneimine) (PEI)- and chitosan-coated alginate microparticles were fabricated demonstrating improved protein retention as well as controlled release. Furthermore, a model protein ovalbumin was loaded along with delta inulin microparticulate adjuvant into the water-core of the alginate microparticles. Compared to those microparticles with only antigen loaded, the antigen + adjuvant loaded microparticles showed a delayed and sustained release of antigen. This microfluidic approach provides a convenient method for making well-controlled alginate microgel particles with uniform size and controlled properties, and demonstrates the ability to tune the release profiles of proteins by engineering microparticle structure and properties. |
Keywords: | Alginates Ovalbumin Delayed-Action Preparations Microfluidic Analytical Techniques Microspheres Particle Size Surface Properties Hydrogel, Polyethylene Glycol Dimethacrylate |
Rights: | © 2018 Elsevier Inc. All rights reserved |
DOI: | 10.1016/j.jcis.2018.12.075 |
Grant ID: | http://purl.org/au-research/grants/arc/LP140100424 http://purl.org/au-research/grants/arc/FT140100726 |
Published version: | http://dx.doi.org/10.1016/j.jcis.2018.12.075 |
Appears in Collections: | Chemical Engineering publications |
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