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https://hdl.handle.net/2440/38009
Type: | Journal article |
Title: | Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis) |
Author: | Schmidt, O. Rahman, M. Ma, G. Theopold, U. Sun, Y. Sarjan, M. Fabbri, M. Roberts, H. |
Citation: | Invertebrate Survival Journal, 2005; 2(2):82-90 |
Publisher: | Universita degli Studi di Modena e Reggio Emilia |
Issue Date: | 2005 |
ISSN: | 1824-307X 1824-307X |
Abstract: | Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defence reactions. But their mode of action, comprising the insertion into cholesterol-containing membranes is not known. Here we explore the mechanical implications of pore-formation by extracellular protein assemblies that drive cellular uptake reactions by leverage-mediated (LM) processes, where oligomeric adhesion molecules bent membrane-receptors around ‘hinge’-like lipophorin particles. The interactions of antimicrobial peptides, pore-forming toxins and biologically active proteins with LMassemblies provide a new paradigm for the configurational specificity and sterical selectivity of biologically active peptides. |
Keywords: | Antimicrobial peptides pore-forming toxins peptide hormones endocytosis lipophorin cholesterol lipid rafts channel formation lectins |
Published version: | http://www.isj.unimo.it/articoli/ISJ104.pdf |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 |
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