Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/46419
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | Novel polyethylene glycol derivative suitable for the preparation of mono-PEGylated protein |
| Author: | Yun, Q. Chen, T. Zhang, G. Bi, J. Ma, G. Su, Z. |
| Citation: | Biotechnology Letters, 2005; 27(3):213-217 |
| Publisher: | Kluwer Academic Publ |
| Issue Date: | 2005 |
| ISSN: | 0141-5492 1573-6776 |
| Statement of Responsibility: | Qiang Yun, Ting Chen, Guifeng Zhang, Jingxiu Bi, Guanghui Ma and Zhiguo Su |
| Abstract: | A novel methoxypolyethylene glycol (mPEG) derivative, containing a reactive group of 1-methyl pyridinium toluene-4-sulfonate, was synthesized and characterized. The mPEG derivative was successfully conjugated with two proteins: recombinant human granulocyte-colony stimulating factor (rhG-CSF) and consensus interferon (C-IFN). Homogeneous mono-PEGylated proteins were obtained which were identified by high performance size-exclusion chromatography and MALDI-TOF mass spectrometry. The biological activities of the mono-PEGylated rhG-CSF and the mono-PEGylated C-IFN were maintained at 90% and 88%, respectively. |
| Keywords: | consensus interferon granulocyte-colony stimulating factor PEGylation polyethylene glycol |
| Description: | The definitive version may be found at www.springerlink.com |
| Rights: | © Springer |
| DOI: | 10.1007/s10529-004-8354-7 |
| Published version: | http://www.springerlink.com/content/v7l8l16385257262/ |
| Appears in Collections: | Aurora harvest Chemical Engineering publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.