Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/63358
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK₁ receptor |
Other Titles: | Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK(1)receptor |
Author: | Little, T. Gopinath, A. Patel, E. McGlone, A. Lassman, D. D'Amato, M. McLaughlin, J. Thompson, D. |
Citation: | Neurogastroenterology and Motility, 2010; 22(11):1183-e314 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2010 |
ISSN: | 1350-1925 1365-2982 |
Statement of Responsibility: | T. J. Little, A. Gopinath, E. Patel, A. Mcglone, D. J. Lassman, M. D’amato, J. T. Mclaughlin & D. G. Thompson |
Abstract: | <h4>Background</h4>It is widely reported that hexose sugars slow gastric emptying (GE) via osmoreceptor stimulation but this remains uncertain. We evaluated the effects of a panel of hexoses of differing molecular structure, assessing the effects of osmolality, intra-individual reproducibility and the role of the CCK(1) receptor, in the regulation of GE by hexoses.<h4>Methods</h4>Thirty one healthy non-obese male and female subjects were studied in a series of protocols, using a (13) C-acetate breath test to evaluate GE of varying concentrations of glucose, galactose, fructose and tagatose, with water, NaCl and lactulose as controls. GE was further evaluated following the administration of a CCK(1) receptor antagonist. Three subjects underwent repeated studies to evaluate intra-individual reproducibility.<h4>Key results</h4>At 250 mOsmol, a hexose-specific effect was apparent: tagatose slowed GE more potently than water, glucose and fructose (P < 0.05). Fructose (P < 0.05) also slowed GE, but with substantial inter-, but not intra-, individual differences. As osmolality increased further the hexose-specific differences were lost. At 500 mOsmol, all hexoses slowed GE compared with water (P < 0.05), whereas lactulose and saline did not. The slowing of GE by hexose sugars appeared to be CCK(1) receptor-dependent.<h4>Conclusions & inferences</h4>The effects of hexose sugars on GE appear related to their molecular structure rather than osmolality per se, and are, at least in part, CCK(1) receptor-dependent. |
Keywords: | dexloxiglumide fructose galactose gastric emptying glucose tagatose. |
Rights: | © 2010 Blackwell Publishing Ltd |
DOI: | 10.1111/j.1365-2982.2010.01552.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2982.2010.01552.x |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.